Article

Reconstitution of Pluripotency from Mouse Fibroblast through Sall4 Overexpression

2023-07-06

Abstract excerpt

<title>Abstract</title> <p>Somatic cells can be reprogrammed into pluripotent stem cells (iPSCs) by overexpressing de-fined transcription factors. Specifically, OCT4 single factor overexpression has been shown to reprogram mouse fibroblasts into iPSCs. Yet, whether other single factor can induce iPSCs from fibroblasts remains unknown. Here, we demonstrate that, under an optimized reprogram-ming medium iCD4, SALL4...

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Literature Corpus work: d8953139-de59-5d13-b45b-54db24895dd3
DOI: 10.21203/rs.3.rs-3052712/v1

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