Article

Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

2017-10-26

Abstract excerpt

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogrammed human somatic cells to a pluripotent embryonic stem cell-like state through the ectopic expression of a combination of embryonic transcription factors was greeted with great excitement by scientists and bioethicists. The reprogrammi...

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Literature Corpus work: 4b84f260-4b37-5b3c-b088-ff6e9f33d78c
DOI: 10.7287/peerj.preprints.3374v1

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