Article

Genomic profiling of T cell activation reveals dependency of memory T cells on CD28 costimulation

2018-09-18

Abstract excerpt

<h4>Summary</h4> T cell activation is a critical driver of immune response and if uncontrolled, it can result in failure to respond to infection or in excessive inflammation and autoimmunity. CD28 costimulatory pathway is an essential regulator of CD4 T cell responses. To deconvolute how T cell receptor (TCR) and CD28 orchestrate activation of human CD4 T cells we stimulated cells using varying intensities of TCR...

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Literature Corpus work: ef435882-f114-5fec-a0f3-bd682a3bdea9
DOI: 10.1101/421099

Open publication

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