Article

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

2025-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Exhausted CD8 T cells (T EX ) arising during chronic infections and cancer have reduced functional capacity and limited fate flexibility that prevents optimal disease control and response to immunotherapies. Compared to memory (T MEM ) cells, T EX have a unique open chromatin landscape underlying a distinct gene expression program. How T EX transcriptional and epigenetic landscapes are regul...

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Literature Corpus work: 3f230926-98df-5648-9257-37dfb59ba5e7
DOI: 10.1101/2025.04.16.649198

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