Article

Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

2022-11-23

Abstract excerpt

T cell activation pathways have been repeatedly implicated by genetic studies as being enriched for risk genes for immune and inflammatory diseases. Many of these risk genes code for costimulatory receptors or ligands. Costimulatory receptors are cell surface proteins on T cells, which are engaged by costimulatory ligands on antigen-presenting cells. Both costimulation and antigen binding are required to trigger T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5810407-180f-5932-9ea5-a95aab3449bf
DOI: 10.1101/2022.11.23.517727

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cellsDOI 10.1101/2022.11.23.517727Read

Autoimmunity risk alleles in costimulation pathways.Semantic proximity Read

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseasesSemantic proximity Read

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activationSemantic proximity Read

Characterising the gene regulatory landscape of CD4+ T cellsSemantic proximity Read

Psoriasis risk allele function in activated Th1/17 cells with "memory" to antigen exposure.Semantic proximity Read

Psoriasis risk allele function in activated Th1/17 cells with "memory" to antigen exposureSemantic proximity Read

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.Semantic proximity Read

Genomic profiling of T cell activation reveals dependency of memory T cells on CD28 costimulationSemantic proximity Read

Immunogenomic approaches to understand the function of immune disease variants.Semantic proximity Read

Intersection of population variation and autoimmunity genetics in human T cell activation.Semantic proximity Read

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseasesSemantic proximity Read