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Article

Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern.

Aging cell - 1 Apr 2017

Suarez-Álvarez Beatriz, Rodríguez Ramón M, Schlangen Karin, Raneros Aroa Baragaño, Márquez-Kisinousky Leonardo, Fernández Agustín F, Díaz-Corte Carmen, Aransay Ana M, López-Larrea Carlos

Abstract excerpt

Aging is associated with a progressive loss of the CD28 costimulatory molecule in CD4+ lymphocytes (CD28null T cells), which is accompanied by the acquisition of new biological and functional properties that give rise to an impaired immune response. The regulatory mechanisms that govern the appearance and function of this cell subset during aging and in several associated inflammatory disorders remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28026094
DOI: 10.1111/acel.12552
PMCID: PMC5334526

Genes

ITK
LCK
RUNX3
TXK
TYROBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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