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Deciphering the role of histone modifications in memory and exhausted CD8 T cells

19 May 2025

Abstract excerpt

Exhausted CD8 T cells (T EX ) arising during chronic infections and cancer have reduced functional capacity and limited fate flexibility that prevents optimal disease control and response to immunotherapies. Compared to memory (T MEM ) cells, T EX have a unique open chromatin landscape underlying a distinct gene expression program. How T EX transcriptional and epigenetic landscapes are regulated through histone...

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PMID: 40389726
DOI: 10.1038/s41598-025-99804-0

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