Article

Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

2020-07-01

Abstract excerpt

<title>Abstract</title> <p>Background Deletion or mutations of SHANK3 lead to Phelan-McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum, and striatum have been associated with behavioral impairments in Shank3-deficient animal models....

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Literature Corpus work: ef3e9016-5dca-5532-9d39-caa6369a5e1d
DOI: 10.21203/rs.2.20698/v2

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