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Article

Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Feb 2008

Hung Albert Y, Futai Kensuke, Sala Carlo, Valtschanoff Juli G, Ryu Jubin, Woodworth Mollie A, Kidd Fleur L, Sung Clifford C, Miyakawa Tsuyoshi, Bear Mark F, Weinberg Richard J, Sheng Morgan

Abstract excerpt

Experience-dependent changes in the structure of dendritic spines may contribute to learning and memory. Encoded by three genes, the Shank family of postsynaptic scaffold proteins are abundant and enriched in the postsynaptic density (PSD) of central excitatory synapses. When expressed in cultured hippocampal neurons, Shank promotes the maturation and enlargement of dendritic spines. Recently, Shank3 has been...

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Identifiers

PMID: 18272690
DOI: 10.1523/JNEUROSCI.3032-07.2008
PMCID: PMC2633411

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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