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Article

Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries.

Cellular and molecular neurobiology - 1 Aug 2022

Wan Lily, Liu Du, Xiao Wen-Biao, Zhang Bo-Xin, Yan Xiao-Xin, Luo Zhao-Hui, Xiao Bo

Abstract excerpt

The Shank family proteins are enriched at the postsynaptic density (PSD) of excitatory glutamatergic synapses. They serve as synaptic scaffolding proteins and appear to play a critical role in the formation, maintenance and functioning of synapse. Increasing evidence from genetic association and animal model studies indicates a connection of SHANK genes defects with the development of neuropsychiatric disorders....

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Identifiers

PMID: 33595806
DOI: 10.1007/s10571-021-01054-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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