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Article

Modeling autism by SHANK gene mutations in mice.

Neuron - 10 Apr 2013

Jiang Yong-Hui, Ehlers Michael D

Abstract excerpt

Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that organize an extensive protein complex at the postsynaptic density (PSD) of excitatory glutamatergic synapses. Recent human genetic studies indicate that SHANK family genes (SHANK1, SHANK2, and SHANK3) are causative genes for idiopathic autism spectrum disorders (ASD). Neurobiological studies of Shank mutations in mice...

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Identifiers

PMID: 23583105
DOI: 10.1016/j.neuron.2013.03.016
PMCID: PMC3659167

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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