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Article

SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain.

Neuroscience - 15 Sept 2023

Huang Chengyu, Voglewede Mikayla M, Ozsen Elif Naz, Wang Hui, Zhang Huaye

Abstract excerpt

Autism Spectrum Disorders (ASD) and schizophrenia are distinct neurodevelopmental disorders that share certain symptoms and genetic components. Both disorders show abnormalities in dendritic spines, which are the main sites of excitatory synaptic inputs. Recent studies have identified the synaptic scaffolding protein Shank3 as a leading candidate gene for both disorders. Mutations in the SHANK3 gene have been...

Topics

Mice
Animals
Autistic Disorder
Dendritic Spines
Schizophrenia
Nerve Tissue Proteins
Autism Spectrum Disorder
Brain
Mutation
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37532012
DOI: 10.1016/j.neuroscience.2023.07.024
PMCID: PMC10528879

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SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain.PMID 37532012Read ↗

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