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Article

Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense <i>Shank3</i> mutation

2020-01-08

Abstract excerpt

The SHANK3 gene encodes a postsynaptic scaffold protein in excitatory synapses, and its disruption is implicated in neurodevelopmental disorders such as Phelan-McDermid syndrome, autism spectrum disorder, and schizophrenia. Most studies of SHANK3 in the neocortex and hippocampus have focused on disturbances in pyramidal neurons. However, GABAergic interneurons likewise receive excitatory inputs and presumably wou...

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Literature Corpus work
823b97a2-c928-56e8-bc51-68e259030c94
DOI
10.1101/2020.01.07.894832
Open publication

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Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense <i>Shank3</i> mutationDOI 10.1101/2020.01.07.894832
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