Article

Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer

2021-01-25

Abstract excerpt

<h4>Background: </h4> ONC201 is a promising first-in-class small molecule that has been reported to have anti-neoplastic activity in various types of cancer through activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as well as activation of mitochondrial caseinolytic protease P (ClpP). <h4>Methods: </h4>: Our objective was to evaluate the effect of the ONC201 on (1) proliferation, cellul...

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Literature Corpus work: ef0e8d97-7a8d-51f4-bfd4-f9e7134d0640
DOI: 10.21203/rs.3.rs-152449/v1

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