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Article

Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC

14 Feb 2019

Abstract excerpt

Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of this study is to investigate the role of SPARC in OvCa interactions with omental adipocytes and its...

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PMID: 30765860
DOI: 10.1038/s41388-019-0728-3

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