Article

Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer

2020-09-29

Abstract excerpt

<title>Abstract</title> <p>BackgroundONC201 is a dopamine receptor D2 (DRD2) antagonist that inhibits tumor growth in preclinical models through ClpP activation to induce integrated stress response pathway and mitochondrial events related to inhibition of cell growth, which is being explored in clinical trials for solid tumors and hematological malignancies. In this study, we investigated the anti-tumorigenic eff...

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Literature Corpus work: a19e491c-6138-5f73-8fdb-306650bf76e1
DOI: 10.21203/rs.3.rs-82585/v1

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