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Article

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.

Science signaling - 16 Feb 2016

Kline C Leah B, Van den Heuvel A Pieter J, Allen Joshua E, Prabhu Varun V, Dicker David T, El-Deiry Wafik S

Abstract excerpt

ONC201 (also called TIC10) is a small molecule that inactivates the cell proliferation- and cell survival-promoting kinases Akt and ERK and induces cell death through the proapoptotic protein TRAIL. ONC201 is currently in early-phase clinical testing for various malignancies. We found through gene expression and protein analyses that ONC201 triggered an increase in TRAIL abundance and cell death through an...

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Identifiers

PMID: 26884600
DOI: 10.1126/scisignal.aac4374
PMCID: PMC4968406

Genes

ATF4
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.PMID 26884600Read ↗

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