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Article

Eliciting OTUD3/RIPK-Dependent Necroptosis to Prevent Epithelial Ovarian Cancer

2020-05-01

Abstract excerpt

<h4>Background</h4> There is an urgent need for early prevention strategies against high grade serous ovarian carcinoma (HGSOC), the deadliest gynecologic malignancy. Transformed p53-null fallopian tube epithelium (FTE) cells are precursors of HGSOC that may be eliminated by inducing necroptosis, a programmed form of inflammatory cell death. Induction of necroptosis is dependent upon activation of receptor-intera...

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Literature Corpus work
a188c8ea-6886-5271-9acd-76508e6f1399
DOI
10.1101/2020.04.29.069021
Open publication

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