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Article

mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity.

Biochemical and biophysical research communications - 30 Sept 2016

Jin Zhe-Zhu, Wang Wei, Fang Di-Long, Jin Yong-Jun

Abstract excerpt

We here tested the anti-colorectal cancer (CRC) activity by a first-in-class small molecule TRAIL inducer ONC201. The potential effect of mTOR on ONC201's actions was also examined. ONC201 induced moderate cytotoxicity against CRC cell lines (HT-29, HCT-116 and DLD-1) and primary human CRC cells. Significantly, AZD-8055, a mTOR kinase inhibitor, sensitized ONC201-induced cytotoxicity in CRC cells. Meanwhile,...

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PMID: 27565731
DOI: 10.1016/j.bbrc.2016.08.126

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DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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