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Article

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer

12 Mar 2018

Abstract excerpt

Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC. Paraoxonase 2 (PON2) is a membrane-associated lactonase with anti-oxidant properties. PON2 deficiency aggravates mitochondrial ROS formation, systemic inflammation, and atherosclerosis. The role of PON2 in...

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PMID: 29531225
DOI: 10.1038/s41419-018-0395-2

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