Article

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

2023-02-01

Abstract excerpt

<h4>Background: </h4> Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is characterized by constitutive activation of Carbohydrate Response Element Binding Protein (ChREBP), a glucose-sensitive transcription factor. Previously, we showed t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eeff854d-8e14-5c3a-abee-55c7c1046086
DOI: 10.21203/rs.3.rs-2514060/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type IaDOI 10.21203/rs.3.rs-2514060/v1Read

Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR-associated protein 9-Mediated Gene Editing.Semantic proximity Read

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.Semantic proximity Read

Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinomaSemantic proximity Read

The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type IaSemantic proximity Read

<i>Ybx1</i> guides C/EBPα and cBAF chromatin-remodeling complex to promote adipogenic gene expression in steatotic hepatocytesSemantic proximity Read

Gene therapy and genome editing for type I glycogen storage diseasesSemantic proximity Read

<i>Gnas</i> <sup>R201C</sup> Induces Murine Pancreatic Cystic Neoplasms through Suppression of YAP1 Signaling and Transcriptional ReprogrammingSemantic proximity Read

Cellular senescence is associated with age-related loss of liver zonation and hepatocyte functionSemantic proximity Read

Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1.Semantic proximity Read

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)Semantic proximity Read

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismSemantic proximity Read

NPAS2 Promotes MASLD and Hepatocarcinogenesis through SIRT1-Mediated PPARγ SuppressionSemantic proximity Read