Cellular senescence is associated with age-related loss of liver zonation and hepatocyte function

Abstract excerpt

The liver is organized into tightly regulated zones with distinct metabolic functions but zonation erodes with age. Cellular senescence contributes to aging and liver diseases, however, its impact on aging biology is ill-defined. As part of The Cellular Senescence Network Consortium, we used multiple spatial transcriptomics approaches (GeoMx, Visium, CosMx) with snRNA-seq to profile senescence signatures, zonation...

Topics

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• Cellular Senescence
• Disease Models, Animal
• Fatty Liver
• Hepatic Stellate Cells
• Liver Cirrhosis
• Mice
• Mice, Inbred C57BL
• Receptors, Urokinase Plasminogen Activator

Identifiers and source

Literature Corpus work

ffe876d8-ec2b-5bc1-8a18-d9bfc81d4f42

DOI

10.64898/2026.08.08.743614