Article

NPAS2 Promotes MASLD and Hepatocarcinogenesis through SIRT1-Mediated PPARγ Suppression

2025-12-03

Abstract excerpt

<title>Abstract</title> <p> Emerging evidence suggests a link between circadian disruption and metabolic dysfunction-associated steatotic liver disease (MASLD), although the precise mechanisms are not yet fully understood. As a central circadian regulator, the role of NPAS2 in the pathogenesis and progression of MASLD to hepatocellular carcinoma (HCC) is not well characterized. This study aimed to clarify the fu...

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Literature Corpus work: 42d4ae1c-14b8-528c-ad2b-b6779d2869fa
DOI: 10.21203/rs.3.rs-8137044/v1

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