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Article

Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1.

PLoS genetics - 1 Dec 2021

Zhang Wenfeng, Wu Chaoying, Ni Rui, Yang Qifen, Luo Lingfei, He Jianbo

Abstract excerpt

The liver is a crucial center in the regulation of energy homeostasis under starvation. Although downregulation of mammalian target of rapamycin complex 1 (mTORC1) has been reported to play pivotal roles in the starvation responses, the underpinning mechanisms in particular upstream factors that downregulate mTORC1 remain largely unknown. To identify genetic variants that cause liver energy disorders during...

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Identifiers

PMID: 34941873
DOI: 10.1371/journal.pgen.1009980
PMCID: PMC8741050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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