Article

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolism

2024-05-25

Abstract excerpt

<h4>Background & aims</h4> Metabolic dysfunction-associated steatohepatitis (MASH) is a multifactorial disease driven by complex molecular mechanisms. Identifying key regulators is critical for developing targeted therapies. Here, we demonstrate the impact of the loss of apoptosis antagonizing transcription factor (AATF) on hepatic lipid metabolism and MASH progression. <h4>Methods</h4> A preclinical mouse model...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b79d919-0fb4-5bdd-92eb-435cfb4bf2d9
DOI: 10.1101/2024.05.25.595878

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismDOI 10.1101/2024.05.25.595878Read

Hepatocyte-Specific Fads1 Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model.Semantic proximity Read

Modulation of metabolic, inflammatory, fibrotic and cell death pathways by Resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): A transcriptomic profiling studySemantic proximity Read

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activationSemantic proximity Read

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progressionSemantic proximity Read

Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.Semantic proximity Read

Thyroid Hormone and Mitochondrial Dysfunction: Therapeutic Implications for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Semantic proximity Read

Sex- and age-associated factors drive the pathophysiology of MASLDSemantic proximity Read

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial functionSemantic proximity Read

Aging promotes inflammation and steatosis in alcohol-associated liver disease in miceSemantic proximity Read

Exercise protects against AMLN diet-induced lipid deposition in hepatocytes during MAFLD progression by regulating the UPRmt and FGF21 secretionSemantic proximity Read

The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular CarcinomaSemantic proximity Read

Orchestration of Gut–Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic InnovationSemantic proximity Read