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Article

The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia

16 Jan 2020

Abstract excerpt

Glucose-6-phosphatase-α (G6Pase-α or G6PC) deficiency in glycogen storage disease type-Ia (GSD-Ia) leads to impaired hepatic autophagy, a recycling process important for cellular metabolism and homeostasis. Autophagy can be regulated by several energy sensing pathways, including sirtuin 1 (SIRT1), forkhead box O (FoxO), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-α (PPAR-α),...

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PMID: 31961433
DOI: 10.1093/hmg/ddaa007

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