Article

<i>Gnas</i> <sup>R201C</sup> Induces Murine Pancreatic Cystic Neoplasms through Suppression of YAP1 Signaling and Transcriptional Reprogramming

2018-04-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Somatic “hotspot” mutations of GNAS , which encodes for the alpha subunit of stimulatory G-protein, are present in ~60% of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. There are currently no cognate animal models that recapitulate the biology of mutant Gnas -induced IPMNs, and the underlying mechanisms that lead to the cystic pathway of neoplasi...

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Literature Corpus work: 6181afb2-8f5b-5d25-a29a-dbf16915e68d
DOI: 10.1101/310292

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