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The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of <i>Clostridioides difficile</i> and commensal <i>Clostridia</i>

2021-11-13

Abstract excerpt

An intact gut microbiota confers colonization resistance against Clostridioides difficile through a variety of mechanisms, likely including competition for nutrients. Recently, proline was identified as an important environmental amino acid that C. difficile uses to support growth and cause significant disease. A post-translationally modified form, trans-4-hydroxyproline, is highly abundant in collagen, which is...

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Literature Corpus work
eecc907b-4e35-50aa-aa6c-f68698ec6b4c
DOI
10.1101/2021.11.12.468462
Open publication

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