Article

Glycine fermentation by <i>C. difficile</i> promotes virulence, spore formation, and is induced by host cathelicidin

2023-06-30

Abstract excerpt

<h4>SUMMARY</h4> The amino acid glycine is enriched in the dysbiotic gut and is suspected to contribute to Clostridioides difficile infection. We hypothesized that the use of glycine as an energy source contributes to colonization of the intestine and pathogenesis of C. difficile . To test this hypothesis, we deleted the glycine reductase genes grdAB , rendering C. difficile unable to ferment glycine, and inv...

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Clostridium difficile and Clostridium perfringens research

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Literature Corpus work: d8387d08-4d35-5a3f-b1e2-890490aa4df8
DOI: 10.1101/2023.06.30.547236

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