Article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

2020-08-06

Abstract excerpt

<h4>Introductory paragraph</h4> Clostridioides difficile is a bacterial pathogen that causes a range of clinical disease from mild to moderate diarrhea, pseudomembranous colitis, and toxic megacolon. Typically, C. difficile infections (CDIs) occur after antibiotic treatment, which alters the gut microbiota, decreasing colonization resistance against C. difficile . Disease is mediated by two large toxins and the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f42d2522-6474-5267-90e3-4d51803c863f
DOI: 10.1101/2020.08.06.238881

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiotaDOI 10.1101/2020.08.06.238881Read

Clostridium difficile colonizes alternative nutrient niches during infection across distinct murine gut microbiomesSemantic proximity Read

Clostridium difficile Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut MicrobiomesSemantic proximity Read

Clostridium difficile exploits a host metabolite produced during toxin-mediated infectionSemantic proximity Read

Clostridium difficile infectionSemantic proximity Read

Dual RNA-seq identifies proteins and pathways modulated during Clostridioides difficile colonisationSemantic proximity Read

Central in vivo mechanisms by which C. difficile’s proline reductase drives efficient metabolism, growth, and toxin productionSemantic proximity Read

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse ModelSemantic proximity Read

Pathogenicity and virulence of Clostridioides difficileSemantic proximity Read

Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficileSemantic proximity Read

Clostridioides difficile phage biology and applicationSemantic proximity Read

Biology of Clostridium difficile: Implications for Epidemiology and DiagnosisSemantic proximity Read

C. difficile exploits a host metabolite produced during toxin-mediated disease.Semantic proximity Read

<i>Clostridioides difficile</i> exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Abstract excerpt

Topics

Identifiers and source

Related research