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Exogenous butyrate inhibits butyrogenic metabolism and alters expression of virulence genes in <i>Clostridioides difficile</i>

2023-07-06

Abstract excerpt

<h4>ABSTRACT</h4> The gut microbiome engenders colonization resistance against the diarrheal pathogen Clostridioides difficile but the molecular basis of this colonization resistance is incompletely understood. A prominent class of gut microbiome-produced metabolites important for colonization resistance against C. difficile is short chain fatty acids (SCFAs). In particular, one SCFA (butyrate) decreases the fi...

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Literature Corpus work
094f62b2-2763-5b94-aaa0-1b7c5db4b970
DOI
10.1101/2023.07.06.548018
Open publication

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Exogenous butyrate inhibits butyrogenic metabolism and alters expression of virulence genes in <i>Clostridioides difficile</i>DOI 10.1101/2023.07.06.548018
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