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The initial gut microbiota and response to antibiotic perturbation influence <i>Clostridioides difficile</i> colonization in mice

2020-08-28

Abstract excerpt

The gut microbiota has a key role in determining susceptibility to Clostridioides difficile infections (CDIs). However, much of the mechanistic work examining CDIs in mouse models use animals obtained from a single source. We treated mice from 6 sources (2 University of Michigan colonies and 4 commercial vendors) with clindamycin, followed by a C. difficile challenge and then measured C. difficile colonization...

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Identifiers and source

Literature Corpus work
4b493a59-2518-573d-ba4d-6f2eb30c9080
DOI
10.1101/2020.08.27.271304
Open publication

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The initial gut microbiota and response to antibiotic perturbation influence <i>Clostridioides difficile</i> colonization in miceDOI 10.1101/2020.08.27.271304
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