Article

<i>Clostridium difficile</i> colonizes alternative nutrient niches during infection across distinct murine gut microbiomes

2016-12-07

Abstract excerpt

Clostridium difficile is the largest single cause of hospital-acquired infection in the United States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to antibiotics, as they disrupt the gut bacterial community which protects from C. difficile colonization. Multiple antibiotic classes have been associated with CDI susceptibility; many leading to distinct community structures stemm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f48538a-e4d5-59fa-ba48-1bd2afc8e0c9
DOI: 10.1101/092304

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Clostridium difficile</i> colonizes alternative nutrient niches during infection across distinct murine gut microbiomesDOI 10.1101/092304Read

<i>Clostridium difficile</i> Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut MicrobiomesSemantic proximity Read

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse ModelSemantic proximity Read

<i>Clostridioides difficile</i> exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiotaSemantic proximity Read

Emerging <i>Clostridioides difficile</i> ribotypes have divergent metabolic phenotypesSemantic proximity Read

<i>Clostridium difficile</i> heterogeneously impacts intestinal community architecture but drives stable metabolome responsesSemantic proximity Read

Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of <i>Clostridioides difficile</i>Semantic proximity Read

Personalized <i>Clostridioides difficile</i> engraftment risk prediction and probiotic therapy assessment in the human gutSemantic proximity Read

The gut bacterial community potentiates <i>Clostridioides difficile</i> infection severitySemantic proximity Read

Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapesSemantic proximity Read

Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infectionsSemantic proximity Read

Structural and functional changes in the gut microbiota associated to Clostridium difficile infectionSemantic proximity Read

Central <i>in vivo</i> mechanisms by which <i>C. difficile’s</i> proline reductase drives efficient metabolism, growth, and toxin productionSemantic proximity Read