Back to search

Article

Central <i>in vivo</i> mechanisms by which <i>C. difficile’s</i> proline reductase drives efficient metabolism, growth, and toxin production

2023-05-20

Abstract excerpt

Clostridioides difficile (CD) is a sporulating and toxin-producing nosocomial pathogen that opportunistically infects the gut, particularly in patients with depleted microbiota after antibiotic exposure. Metabolically, CD rapidly generates energy and substrates for growth from Stickland fermentations of amino acids, with proline being a preferred reductive substrate. To investigate the in vivo effects of reductiv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b631d037-486e-5b04-88a4-7f14f7fd0b78
DOI
10.1101/2023.05.19.541423
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Central <i>in vivo</i> mechanisms by which <i>C. difficile’s</i> proline reductase drives efficient metabolism, growth, and toxin productionDOI 10.1101/2023.05.19.541423
The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of <i>Clostridioides difficile</i> and commensal <i>Clostridia</i>Semantic proximity
<i>Clostridioides difficile</i> exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiotaSemantic proximity
Clostridium difficile exploits a host metabolite produced during toxin-mediated infectionSemantic proximity
Emerging <i>Clostridioides difficile</i> ribotypes have divergent metabolic phenotypesSemantic proximity
<i>Clostridium difficile</i> colonizes alternative nutrient niches during infection across distinct murine gut microbiomesSemantic proximity
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonizationSemantic proximity
Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse ModelSemantic proximity
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of <i>Clostridioides difficile</i>Semantic proximity
<i>Clostridium difficile</i> Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut MicrobiomesSemantic proximity
C. difficile exploits a host metabolite produced during toxin-mediated disease.Semantic proximity
<i>Clostridioides difficile</i> -mucus interactions encompass shifts in gene expression, metabolism, and biofilm formationSemantic proximity
An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in <i>Candida albicans</i> during host infectionSemantic proximity
Select a neighboring publication to make it the new centre.