Genome-wide Association Study of Complex Lipid Species: Results from the Population-based Rhineland Study

Abstract excerpt

The human lipidome comprises numerous complex lipids, dysregulation of which can contribute to the pathogenesis of a wide range of diseases. Despite the high heritability of parts of the lipidome, the genetic architecture of many circulating lipid species and their structure remains mostly unknown. Thus, we performed genome-wide association studies on 970 lipid species and 267 fatty acid composite measures using s...

Topics

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• Coronary Artery Disease
• Fatty Acids
• Genome-Wide Association Study
• Lipid Metabolism
• Lipidomics
• Lipids
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

eec044b0-8cc5-5294-9abb-5b4716a49a99

DOI

10.1101/2024.12.04.24318368