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Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

2021-08-25

Abstract excerpt

We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species that are putatively in the mechanistic pathway to coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 phenotyped individuals from the Busselton Health Study. In our discovery GWAS we identified 667 independent loci associations with...

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Literature Corpus work
d39f780a-887b-5f63-9d42-8782403587fe
DOI
10.1101/2021.08.20.21261814
Open publication

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Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery diseaseDOI 10.1101/2021.08.20.21261814
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