Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.

doi:10.1038/s41467-022-30875-7

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Article

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.

Nature communications - 6 Jun 2022

Cadby Gemma, Giles Corey, Melton Phillip E, Huynh Kevin, Mellett Natalie A, Duong Thy, Nguyen Anh, Cinel Michelle, Smith Alex, Olshansky Gavriel, Wang Tingting, Brozynska Marta, Inouye Mike, McCarthy Nina S, Ariff Amir, Hung Joseph, Hui Jennie, Beilby John, Dubé Marie-Pierre, Watts Gerald F, Shah Sonia, Wray Naomi R, Lim Wei Ling Florence, Chatterjee Pratishtha, Martins Ian, Laws Simon M, Porter Tenielle, Vacher Michael, Bush Ashley I, Rowe Christopher C, Villemagne Victor L, Ames David, Masters Colin L, Taddei Kevin, Arnold Matthias, Kastenmüller Gabi, Nho Kwangsik, Saykin Andrew J, Han Xianlin, Kaddurah-Daouk Rima, Martins Ralph N, Blangero John, Meikle Peter J, Moses Eric K

Abstract excerpt

We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667...

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PMID: 35668104
DOI: 10.1038/s41467-022-30875-7
PMCID: PMC9170690

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