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Article

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.

Nature communications - 31 Oct 2023

Ottensmann Linda, Tabassum Rubina, Ruotsalainen Sanni E, Gerl Mathias J, Klose Christian, Widén Elisabeth, Simons Kai, Ripatti Samuli, Pirinen Matti

Abstract excerpt

The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37907536
DOI: 10.1038/s41467-023-42532-8
PMCID: PMC10618167

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