Article
Human plasma lipidome is pleiotropically associated with cardiovascular risk factors and death.
Circulation. Cardiovascular genetics - 1 Dec 2014
Bellis Claire, Kulkarni Hemant, Mamtani Manju, Kent Jack W, Wong Gerard, Weir Jacquelyn M, Barlow Christopher K, Diego Vincent, Almeida Marcio, Dyer Thomas D, Göring Harald H H, Almasy Laura, Mahaney Michael C, Comuzzie Anthony G, Williams-Blangero Sarah, Meikle Peter J, Blangero John, Curran Joanne E
Abstract excerpt
BACKGROUND: Cardiovascular disease (CVD) is the most common cause of death in the United States and is associated with a high economic burden. Prevention of CVD focuses on controlling or improving the lipid profile of patients at risk. The human lipidome is made up of thousands of ubiquitous lipid species. By studying biologically simple canonical lipid species, we investigated whether the lipidome is genetically...
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