Article

Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity

2025-04-24

Abstract excerpt

Human midbrain organoids (hMOs) show promise as a patient-derived model for the study of Parkinson's disease (PD). Yet, much remains unknown about how accurately hMOs recapitulate key features of PD in the human brain. In both PD patients and animal models, disease progression leads to characteristic changes in neural activity throughout the basal ganglia. Here we demonstrate that patient-derived induced pluripote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b98f40d-922e-5f7a-a0a8-80c614fafc5a
DOI: 10.1101/2025.04.23.650231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activityDOI 10.1101/2025.04.23.650231Read

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathySemantic proximity Read

Midbrain organoids with an <i>SNCA</i> gene triplication model key features of synucleinopathySemantic proximity Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> geneSemantic proximity Read

Identification of neural oscillations and epileptiform changes in human brain organoidsSemantic proximity Read

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays.Semantic proximity Read

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s diseaseSemantic proximity Read

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screeningSemantic proximity Read

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsSemantic proximity Read

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.Semantic proximity Read

Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations.Semantic proximity Read