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Article

Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations.

Annals of neurology - 1 Sept 2021

Jo Junghyun, Yang Lin, Tran Hoang-Dai, Yu Weonjin, Sun Alfred Xuyang, Chang Ya Yin, Jung Byung Chul, Lee Seung-Jae, Saw Tzuen Yih, Xiao Bin, Khoo Audrey Tze Ting, Yaw Lai-Ping, Xie Jessica Jiaxin, Lokman Hidayat, Ong Wei-Yi, Lim Grace Gui Yin, Lim Kah-Leong, Tan Eng-King, Ng Huck-Hui, Je Hyunsoo Shawn

Abstract excerpt

OBJECTIVE: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson disease, with the particular aim of recapitulating α-syn- and Lewy body-related pathologies and the process of neurodegeneration in the hMLO model. METHODS: We...

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Identifiers

PMID: 34288055
DOI: 10.1002/ana.26166
PMCID: PMC9543721

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