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Article

<i>SNCA</i> triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

2025-05-28

Abstract excerpt

Synucleinopathies, including Parkinson’s disease, are characterized by α-synuclein (SNCA) aggregation and progressive neurodegeneration, yet the early molecular events linking SNCA gene dosage to disrupted proteostasis remain poorly understood. Here, we used human midbrain organoids derived from induced pluripotent stem cells (iPSC) carrying an SNCA triplication ( SNCA Trip) and the isogenic corrected line ( S...

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Literature Corpus work
84f71749-85bc-535e-8ed5-86ec6c048a13
DOI
10.1101/2025.05.28.656641
Open publication

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<i>SNCA</i> triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoidsDOI 10.1101/2025.05.28.656641
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