Article

The schizophrenia associated protein DISC1 is a multivalent tetrameric hub of conserved ancient fold

2026-01-30

Abstract excerpt

DISC1 is a pleiotropic protein with essential roles in neuronal proliferation and migration, intracellular signalling and cargo transport. It associates with a diverse array of partner molecules in these contexts. Mutations at the DISC1 locus are strongly associated with a spectrum of mental illnesses such as schizophrenia and depression. Despite its clinical relevance, the molecular architecture and function of...

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Literature Corpus work: ee56a985-92c6-503c-b41b-b92a3095f0c9
DOI: 10.64898/2026.01.28.701986

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