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Article

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.

Molecular and cellular neurosciences - 1 Apr 2005

Brandon N J, Schurov I, Camargo L M, Handford E J, Duran-Jimeniz B, Hunt P, Millar J K, Porteous D J, Shearman M S, Whiting P J

Abstract excerpt

Disrupted in schizophrenia 1 (DISC1) has been identified as a putative risk factor for schizophrenia and affective disorders through study of a Scottish family with a balanced (1;11) (q42.1;q14.3) translocation, which results in the disruption of the DISC1 locus and cosegregates with major psychiatric disease. Several other reports of genetic linkage and association between DISC1 and schizophrenia in a range of...

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Source

Identifiers

PMID: 15797709
DOI: 10.1016/j.mcn.2004.11.003

Genes

DISC1
FEZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.PMID 15797709Read ↗

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.Semantic proximity Read ↗

Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowthSemantic proximity Read ↗

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondriaSemantic proximity Read ↗

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic ImagingSemantic proximity Read ↗

Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria.Semantic proximity Read ↗

Mitochondrial roles of the psychiatric disease risk factor DISC1.Semantic proximity Read ↗

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.Semantic proximity Read ↗

Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.Semantic proximity Read ↗

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingSemantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Key Regulator Unifying Neurodevelopment and Synaptic FunctionSemantic proximity Read ↗

Understanding the role of DISC1 in psychiatric disease and during normal development.Semantic proximity Read ↗

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