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Article

Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.

The Journal of biological chemistry - 23 Dec 2011

Narayanan Saravanakumar, Arthanari Haribabu, Wolfe Michael S, Wagner Gerhard

Abstract excerpt

DISC1 (Disrupted in schizophrenia-1) plays essential roles in neuronal proliferation, neuronal migration and axon guidance and has been implicated in schizophrenia and related psychiatric disorders. DISC1 forms a functional complex with nuclear distribution element-like protein-1 (NDEL1), a key component that regulates microtubule organization during cell division and neuronal migration. DISC1 polymorphisms at...

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Source

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Identifiers

PMID: 21998303
DOI: 10.1074/jbc.M111.271593
PMCID: PMC3243500

Genes

DISC1
NDEL1

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.PMID 21998303Read ↗

DISCopathies: brain disorders related to DISC1 dysfunction.Semantic proximity Read ↗

Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the proteinSemantic proximity Read ↗

The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity.Semantic proximity Read ↗

Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.Semantic proximity Read ↗

The schizophrenia associated protein DISC1 is a multivalent tetrameric hub of conserved ancient foldSemantic proximity Read ↗

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.Semantic proximity Read ↗

What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?Semantic proximity Read ↗

How has DISC1 enabled drug discovery?Semantic proximity Read ↗

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingSemantic proximity Read ↗

Disrupted in schizophrenia 1: building brains and memories.Semantic proximity Read ↗

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.Semantic proximity Read ↗

Disrupted‐in‐Schizophrenia‐1 (DISC1)Semantic proximity Read ↗

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