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Article

How has DISC1 enabled drug discovery?

Molecular and cellular neurosciences - 1 Feb 2008

Wang Qi, Jaaro-Peled Hanna, Sawa Akira, Brandon Nicholas J

Abstract excerpt

Growing genetic and clinical evidence has shown that disrupted-in-schizophrenia 1 (DISC1) is one of the most compelling risk genes for schizophrenia and other major mental disorders. The understanding of the role that DISC1 plays in neuronal development and cell signaling has been greatly enhanced by the identification of DISC1 binding partners, an appreciation of its expression during development and functional...

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Source

Identifiers

PMID: 18055216
DOI: 10.1016/j.mcn.2007.10.006

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Disrupted in schizophrenia 1: building brains and memories.Semantic proximity Read ↗

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Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.Semantic proximity Read ↗

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