Article
A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.
The Journal of biological chemistry - 21 Apr 2017
Yerabham Antony S K, Mas Philippe J, Decker Christina, Soares Dinesh C, Weiergräber Oliver H, Nagel-Steger Luitgard, Willbold Dieter, Hart Darren J, Bradshaw Nicholas J, Korth Carsten
Abstract excerpt
Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurodevelopment and a prominent candidate protein in the pathology of major mental illness. DISC1 modulates a number of critical neuronal signaling pathways through protein-protein interactions; however, the mechanism by which this occurs and how DISC1 causes mental illness is unclear, partly because knowledge of the...
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