Article
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.
Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2016
Duffy Supipi, Fam Hok Khim, Wang Yi Kan, Styles Erin B, Kim Jung-Hyun, Ang J Sidney, Singh Tejomayee, Larionov Vladimir, Shah Sohrab P, Andrews Brenda, Boerkoel Cornelius F, Hieter Philip
Abstract excerpt
Somatic copy number amplification and gene overexpression are common features of many cancers. To determine the role of gene overexpression on chromosome instability (CIN), we performed genome-wide screens in the budding yeast for yeast genes that cause CIN when overexpressed, a phenotype we refer to as dosage CIN (dCIN), and identified 245 dCIN genes. This catalog of genes reveals human orthologs known to be...
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