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Article

Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability.

Genetics - 1 Mar 2008

Strome Erin D, Wu Xiaowei, Kimmel Marek, Plon Sharon E

Abstract excerpt

Current techniques for identifying mutations that convey a small increased cancer risk or those that modify cancer risk in carriers of highly penetrant mutations are limited by the statistical power of epidemiologic studies, which require screening of large populations and candidate genes. To identify dosage-sensitive genes that mediate genomic stability, we performed a genomewide screen in Saccharomyces...

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Source

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Identifiers

PMID: 18245329
DOI: 10.1534/genetics.107.084103
PMCID: PMC2278055

Genes

CHEK2
ERCC4
TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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