Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

1 Dec 2019

Abstract excerpt

BACKGROUND: The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed significant changes in gene expression and lipids in Alzheimer's disease (AD) brain. The results so far have prompted further research using "multi-omics" approaches. These approaches become particularly relevant, considering the inheritance of APOEε4 allele as a major genetic risk factor of AD,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Metabolomics and Mass Spectrometry Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31888770
DOI: 10.1186/s13195-019-0558-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brainPMID 31888770Read ↗

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.Semantic proximity Read ↗

APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.Semantic proximity Read ↗

<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity Read ↗

Proteomic Insight Into Alzheimer's Disease Pathogenesis PathwaysSemantic proximity Read ↗

Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions.Semantic proximity Read ↗

APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

Ontological Analysis of Brain Proteostasis Highlights the Sex-Dependent Trajectory of ApoE Isoform-Specific RegulationSemantic proximity Read ↗

Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discoverySemantic proximity Read ↗

Transcriptomic analysis of lipid metabolism genes in Alzheimer’s disease: highlighting pathological outcomes and compartmentalized immune statusSemantic proximity Read ↗

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.Semantic proximity Read ↗

Alzheimer's brains show inter-related changes in RNA and lipid metabolismSemantic proximity Read ↗

Proteomic signatures of the <i>APOE ε4</i> and <i>APOE ε2</i> genetic variants and Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.